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Nevus Phakomatoses, Organoid

MedGen UID:
75564
•Concept ID:
C0265329
•
Disease or Syndrome
Synonyms: Feuerstein Mims Syndrome; Feuerstein-Mims Syndrome; Nevus Phakomatosis, Organoid; Organoid Nevus Phakomatoses; Organoid Nevus Phakomatosis; Phakomatoses, Organoid Nevus; Phakomatosis, Organoid Nevus; Schimmelpenning Feuerstein Mims Syndrome; Schimmelpenning Syndrome; Schimmelpenning-Feuerstein-Mims Syndrome; Syndrome, Feuerstein-Mims; Syndrome, Schimmelpenning; Syndrome, Schimmelpenning-Feuerstein-Mims

Professional guidelines

PubMed

An update on Becker's nevus: Pathogenesis and treatment.
Zhou YJ, Zheng DL, Hamblin MR, Xu YD, Wen X
Dermatol Ther 2022 Jul;35(7):e15548. Epub 2022 May 12 doi: 10.1111/dth.15548. PMID: 35502558
Phenotype/genotype correlations in epidermal nevus syndrome as a neurocristopathy.
Flores-Sarnat L, Sarnat HB
Handb Clin Neurol 2015;132:9-25. doi: 10.1016/B978-0-444-62702-5.00002-0. PMID: 26564069
Sebaceus and Becker's Nevus: Overview of Their Presentation, Pathogenesis, Associations, and Treatment.
Patel P, Malik K, Khachemoune A
Am J Clin Dermatol 2015 Jun;16(3):197-204. doi: 10.1007/s40257-015-0123-y. PMID: 25782676

Recent clinical studies

Etiology

Inflammatory linear verrucous epidermal nevus (ILVEN) encompasses a spectrum of inflammatory mosaic disorders.
Atzmony L, Ugwu N, Hamilton C, Paller AS, Zech L, Antaya RJ, Choate KA
Pediatr Dermatol 2022 Nov;39(6):903-907. Epub 2022 Jul 19 doi: 10.1111/pde.15094. PMID: 35853659Free PMC Article
Cd34+ Stromal Cells/Telocytes in Normal and Pathological Skin.
Díaz-Flores L, Gutiérrez R, García MP, González-Gómez M, Rodríguez-Rodriguez R, Hernández-León N, Díaz-Flores L Jr, Carrasco JL
Int J Mol Sci 2021 Jul 8;22(14) doi: 10.3390/ijms22147342. PMID: 34298962Free PMC Article
Sebaceous Nevus of the Scalp.
Goel P, Wolfswinkel EM, Fahradyan A, Tsuha M, Hough M, Magee W 3rd, Hammoudeh JA, Urata MM, Howell LK
J Craniofac Surg 2020 Jan/Feb;31(1):257-260. doi: 10.1097/SCS.0000000000006007. PMID: 31725502
Syndromic sebaceous nevus: current findings.
El Ezzi O, de Buys Roessingh AS, Bigorre M, Captier G
Int J Dermatol 2018 May;57(5):599-604. Epub 2018 Feb 16 doi: 10.1111/ijd.13942. PMID: 29453776
Phenotype/genotype correlations in epidermal nevus syndrome as a neurocristopathy.
Flores-Sarnat L, Sarnat HB
Handb Clin Neurol 2015;132:9-25. doi: 10.1016/B978-0-444-62702-5.00002-0. PMID: 26564069

Diagnosis

Verrucous epidermal nevus.
Rivera-Silva G, Moreno-Treviño MG
Pan Afr Med J 2023;45:146. Epub 2023 Aug 2 doi: 10.11604/pamj.2023.45.146.40966. PMID: 37808438Free PMC Article
Inflammatory linear verrucous epidermal nevus (ILVEN) encompasses a spectrum of inflammatory mosaic disorders.
Atzmony L, Ugwu N, Hamilton C, Paller AS, Zech L, Antaya RJ, Choate KA
Pediatr Dermatol 2022 Nov;39(6):903-907. Epub 2022 Jul 19 doi: 10.1111/pde.15094. PMID: 35853659Free PMC Article
Becker's nevus.
Baalann KP, Krishnan M
Pan Afr Med J 2022;41:142. Epub 2022 Feb 17 doi: 10.11604/pamj.2022.41.142.33417. PMID: 35519166Free PMC Article
Systematized Sebaceous Nevus.
Zhang LL, Liu ZH
J Cutan Med Surg 2022 Nov-Dec;26(6):643. Epub 2022 Mar 23 doi: 10.1177/12034754221088568. PMID: 35321589
Schimmelpenning syndrome.
Resende C, Araújo C, Vieira AP, Ventura F, Brito C
Dermatol Online J 2013 Oct 16;19(10):20026. PMID: 24139367

Therapy

Inflammatory linear verrucous epidermal nevus (ILVEN) encompasses a spectrum of inflammatory mosaic disorders.
Atzmony L, Ugwu N, Hamilton C, Paller AS, Zech L, Antaya RJ, Choate KA
Pediatr Dermatol 2022 Nov;39(6):903-907. Epub 2022 Jul 19 doi: 10.1111/pde.15094. PMID: 35853659Free PMC Article
Safety and effectiveness of 5-aminolevulinic acid photodynamic therapy combined with fractional micro-plasma radio-frequency treatment for verrucous epidermal nevus: A retrospective study with long-term follow-up.
Dai S, He S, Huang X, Chen P, Li Q, Guo J, Zhu M, Shen J, Zeng K
J Dermatol 2021 Aug;48(8):1229-1235. Epub 2021 Apr 25 doi: 10.1111/1346-8138.15923. PMID: 33896053
Bilateral Systematised Epidermolytic Epidermal Nevus: A case report.
Kerawala SR, Rizvi NU, Tabassum S
Sultan Qaboos Univ Med J 2021 Feb;21(1):e124-e126. Epub 2021 Mar 15 doi: 10.18295/squmj.2021.21.01.018. PMID: 33777434Free PMC Article
Verrucous epidermal nevus.
Kim R, Marmon S, Kaplan J, Kamino H, Pomeranz MK
Dermatol Online J 2013 Dec 16;19(12):20707. PMID: 24364998
Difficult-to-control bleeding.
Bellet JS, Wagner AM
Pediatr Dermatol 2009 Sep-Oct;26(5):559-62. doi: 10.1111/j.1525-1470.2009.00985.x. PMID: 19840310

Prognosis

Sebaceous Nevus of the Scalp.
Goel P, Wolfswinkel EM, Fahradyan A, Tsuha M, Hough M, Magee W 3rd, Hammoudeh JA, Urata MM, Howell LK
J Craniofac Surg 2020 Jan/Feb;31(1):257-260. doi: 10.1097/SCS.0000000000006007. PMID: 31725502
Linear Verrucous Epidermal Nevus.
Gupta A, Rai R
Indian Pediatr 2019 Nov 15;56(11):981. PMID: 31729336
Syndromic sebaceous nevus: current findings.
El Ezzi O, de Buys Roessingh AS, Bigorre M, Captier G
Int J Dermatol 2018 May;57(5):599-604. Epub 2018 Feb 16 doi: 10.1111/ijd.13942. PMID: 29453776
Phenotype/genotype correlations in epidermal nevus syndrome as a neurocristopathy.
Flores-Sarnat L, Sarnat HB
Handb Clin Neurol 2015;132:9-25. doi: 10.1016/B978-0-444-62702-5.00002-0. PMID: 26564069
The Muir-Torre syndrome: a 25-year retrospect.
Schwartz RA, Torre DP
J Am Acad Dermatol 1995 Jul;33(1):90-104. doi: 10.1016/0190-9622(95)90017-9. PMID: 7601953

Clinical prediction guides

Reversibility and developmental neuropathology of linear nevus sebaceous syndrome caused by dysregulation of the RAS pathway.
Kim YE, Kim YS, Lee HE, So KH, Choe Y, Suh BC, Kim JH, Park SK, Mathern GW, Gleeson JG, Rah JC, Baek ST
Cell Rep 2023 Jan 31;42(1):112003. Epub 2023 Jan 14 doi: 10.1016/j.celrep.2023.112003. PMID: 36641749
Sebaceous Nevus of the Scalp.
Goel P, Wolfswinkel EM, Fahradyan A, Tsuha M, Hough M, Magee W 3rd, Hammoudeh JA, Urata MM, Howell LK
J Craniofac Surg 2020 Jan/Feb;31(1):257-260. doi: 10.1097/SCS.0000000000006007. PMID: 31725502
Dermoscopy of Adnexal Tumors.
Zaballos P, Gómez-Martín I, Martin JM, Bañuls J
Dermatol Clin 2018 Oct;36(4):397-412. Epub 2018 Aug 16 doi: 10.1016/j.det.2018.05.007. PMID: 30201149
Phenotype/genotype correlations in epidermal nevus syndrome as a neurocristopathy.
Flores-Sarnat L, Sarnat HB
Handb Clin Neurol 2015;132:9-25. doi: 10.1016/B978-0-444-62702-5.00002-0. PMID: 26564069
Verrucous epidermal nevus.
Kim R, Marmon S, Kaplan J, Kamino H, Pomeranz MK
Dermatol Online J 2013 Dec 16;19(12):20707. PMID: 24364998

Recent systematic reviews

Syringocystadenocarcinoma papilliferum: a systematic review of clinical characteristics, reappraisal of associations, diagnostic pitfalls and management challenges.
Wan L, Park A, Khachemoune A
Arch Dermatol Res 2024 Jun 21;316(7):421. doi: 10.1007/s00403-024-03176-w. PMID: 38904691
Rate of Benign and Malignant Secondary Tumors Associated With Nevus Sebaceous: A Systematic Review and Meta-Analysis.
Pang S, Cevik J, Sreedharan S, Wilks DJ
Ann Plast Surg 2024 Jun 1;92(6):711-719. Epub 2024 May 9 doi: 10.1097/SAP.0000000000003879. PMID: 38725109
Dermoscopy of cutaneous adnexal tumours: a systematic review of the literature.
Lai M, Muscianese M, Piana S, Chester J, Borsari S, Paolino G, Pellacani G, Longo C, Pampena R
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1524-1540. Epub 2022 May 25 doi: 10.1111/jdv.18210. PMID: 35536546Free PMC Article

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